Study of desmoglein 1 and 3 antibody levels in relation to disease severity in Indian patients with pemphigus.
Indian J Dermatol Venereol Leprol
;
2006 May-Jun; 72(3): 203-6
Artículo
en Inglés
| IMSEAR
| ID: sea-52033
ABSTRACT
OBJECTIVES:
To conduct a cross-sectional study to compare Dsg1 and Dsg3 antibody levels independently with severity of disease activity in pemphigus vulgaris (PV) and pemphigus foliaceus (PF).METHODS:
Blood samples from 44 patients with pemphigus (PV-38, PF-6) were analyzed using ELISA. The severity of skin and mucosal disease was graded using a score from 0 to 3.RESULTS:
A statistically significant correlation between increase in Dsg 3 antibody titres with severity of oral involvement and Dsg 1 titres with severity of skin involvement was found in both PV and PF patients (p < 0.01). However, we were unable to demonstrate a relationship between increased titres of Dsg1 and Dsg 3 antibodies with oral and skin involvement respectively.CONCLUSION:
This study suggests that the severity of skin and oral disease in pemphigus is determined by the quantities of Dsg1 and Dsg3 antibodies respectively.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Femenino
/
Humanos
/
Masculino
/
Ensayo de Inmunoadsorción Enzimática
/
Estudios de Casos y Controles
/
Niño
/
Estudios Transversales
/
Adolescente
/
Pénfigo
/
Adulto
Tipo de estudio:
Estudio observacional
/
Estudio de prevalencia
/
Factores de riesgo
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Indian J Dermatol Venereol Leprol
Año:
2006
Tipo del documento:
Artículo
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