Adverse effects of antiretroviral treatment.
Indian J Dermatol Venereol Leprol
;
2008 May-Jun; 74(3): 234-7
Artículo
en Inglés
| IMSEAR
| ID: sea-52720
ABSTRACT
BACKGROUND:
The introduction of highly active antiretroviral therapy (HAART) has led to significant reduction in acquired immune deficiency syndrome (AIDS)-related morbidity and mortality. Adverse drug reactions (ADRs) to antiretroviral treatment (ART) are however, major obstacles in its success.AIMS:
We sought to study the adverse effects of ART in a resource-restricted setting in India.METHODS:
Hundred patients on ART were studied prospectively over a period of two years. All patients were asked to visit the clinic if they developed any symptoms or on a monthly basis. They were screened clinically and investigated suitably for any ADRs.RESULT:
Out of the 100 patients, ten patients did not come for follow-up; only 90 cases were available for evaluation. ADRs were observed in 64 cases (71.1%) - the maximal frequency of ADRs was seen with zidovudine (AZT) (50%) followed by stavudine (d4T) (47.9%), efavirenz (EFV) (45.4%) and finally, Nevirapine (NVP) (18.4%). Most common ADRs were cutaneous (44.4%) followed by hematological (32.2%), neurological (31.1%), metabolic (22.2%) and gastrointestinal (20%). Most common cutaneous ADRs observed were nail hyperpigmentation (14.4%) and rash (13.3%). Immune reconstitution inflammatory syndrome (IRIS) was observed as a paradoxical reaction to ART in 20 (22.2%) cases.CONCLUSION:
To optimize adherence and thus, efficacy of ART, clinicians must focus on preventing adverse effects whenever possible, and distinguish those that are self-limited from those that are potentially serious.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Femenino
/
Humanos
/
Masculino
/
Infecciones por VIH
/
Estudios Prospectivos
/
Estudios de Seguimiento
/
Hiperpigmentación
/
Erupciones por Medicamentos
/
Enfermedades del Sistema Nervioso Periférico
/
Antirretrovirales
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
Idioma:
Inglés
Revista:
Indian J Dermatol Venereol Leprol
Año:
2008
Tipo del documento:
Artículo
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