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Dexamethasone-cyclophosphamide pulse therapy in systemic lupus erythematosus.
Indian J Dermatol Venereol Leprol ; 2005 Jan-Feb; 71(1): 9-13
Artículo en Inglés | IMSEAR | ID: sea-53074
ABSTRACT
BACKGROUND AND

AIMS:

Therapy systemic lupus erythematosus (SLE) has been generally discouraging. Methyl-prednisolone pulse therapy has been used for various connective tissue disorders. We used intravenous dexamethasone cyclophosphamide pulse therapy to treat SLE.

METHODS:

Fourteen patients (10 females and 4 males) between the age of 15-48 years with definite or classical clinical criteria laid by American Rheumatism Association criteria were treated by Dexamethasone-Cyclophosphamide pulse (DCP) therapy at our center.

RESULTS:

It was possible to induce a complete clinical remission with DCP therapy in most of the patients thereby offering them life free from disease and drugs. The side effects commonly observed with conventional daily dose regimen of corticosteroids were not present or were mild.

CONCLUSIONS:

Almost all patients had good response after 3-4 pulses to allow them a normal life style. Fever, malar rash and oral ulceration responded early but photosensitivity, discoid rash, alopecia and joint pains took some more time.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Índice de Severidad de la Enfermedad / Femenino / Humanos / Masculino / Dexametasona / Estudios Prospectivos / Estudios Retrospectivos / Estudios de Seguimiento / Adolescente / Resultado del Tratamiento Tipo de estudio: Estudio de etiología / Estudio observacional / Estudio pronóstico / Factores de riesgo País/Región como asunto: Asia Idioma: Inglés Revista: Indian J Dermatol Venereol Leprol Año: 2005 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Índice de Severidad de la Enfermedad / Femenino / Humanos / Masculino / Dexametasona / Estudios Prospectivos / Estudios Retrospectivos / Estudios de Seguimiento / Adolescente / Resultado del Tratamiento Tipo de estudio: Estudio de etiología / Estudio observacional / Estudio pronóstico / Factores de riesgo País/Región como asunto: Asia Idioma: Inglés Revista: Indian J Dermatol Venereol Leprol Año: 2005 Tipo del documento: Artículo