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Severe cutaneous adverse drug reaction to leflunomide: a report of five cases.
Indian J Dermatol Venereol Leprol ; 2006 Jul-Aug; 72(4): 286-9
Artículo en Inglés | IMSEAR | ID: sea-53139
ABSTRACT
Medications used to treat human ailments are known to cause cutaneous reactions which may vary in their severity. Leflunomide, an immunomodulating agent recently introduced to treat rheumatoid arthritis, is reported to cause severe cutaneous reactions. We are reporting five such cases. All our patients were started on leflunomide for rheumatoid arthritis, 4-6 weeks before the onset of cutaneous reaction and were admitted to the hospital with the common complaints of fever, skin rash and generalized weakness. All of them had characteristic pattern of events such as delayed onset of reaction, widespread and long lasting skin rash and internal organ involvement. These features suggest a possibility of drug hypersensitivity syndrome to leflunomide. Careful dosing and periodic monitoring of patients treated with leflunomide for possible adverse drug reaction is recommended.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Artritis Reumatoide / Esteroides / Índice de Severidad de la Enfermedad / Femenino / Humanos / Masculino / Erupciones por Medicamentos / Adulto / Isoxazoles / Persona de Mediana Edad Idioma: Inglés Revista: Indian J Dermatol Venereol Leprol Año: 2006 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Artritis Reumatoide / Esteroides / Índice de Severidad de la Enfermedad / Femenino / Humanos / Masculino / Erupciones por Medicamentos / Adulto / Isoxazoles / Persona de Mediana Edad Idioma: Inglés Revista: Indian J Dermatol Venereol Leprol Año: 2006 Tipo del documento: Artículo