Aciclovir resistance among Indian strains of Herpes simplex virus as determined using a dye uptake assay.
Indian J Med Microbiol
;
2007 Jul; 25(3): 260-2
Artículo
en Inglés
| IMSEAR
| ID: sea-53477
ABSTRACT
Resistance to aciclovir (ACV) among Herpes simplex virus (HSV) isolates is increasingly being reported in the literature particularly in immunocompromised patients. However, there is only limited data available from India despite widespread use of ACV in our hospital. A cross-sectional study was hence conducted to determine the aciclovir (ACV) susceptibility of HSV 1 and 2 isolates using a dye uptake (DU) assay. This study showed a 3.0% prevalence of ACV resistance among HSV-1 strains (2/66, median IC 50 0.098 microg/mL) while in HSV-2 strains, it was 7.8% (5/64, median IC 50 0.195 microg/mL). The IC 50 for the HSV-1 and HSV-2 strains resistant to ACV was greater than or equal to 6.25 microg/mL.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Antivirales
/
Virología
/
Humanos
/
Aciclovir
/
Pruebas de Sensibilidad Microbiana
/
Estudios Transversales
/
Simplexvirus
/
Farmacorresistencia Viral
/
India
Tipo de estudio:
Estudio observacional
/
Estudio de prevalencia
/
Factores de riesgo
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Indian J Med Microbiol
Asunto de la revista:
Microbiology
Año:
2007
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS