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In vitro and in vivo interactions of drugs used in multidrug therapy in leprosy.
Indian J Lepr ; 1991 Apr-Jun; 63(2): 166-79
Artículo en Inglés | IMSEAR | ID: sea-54510
ABSTRACT
Interactions of different drugs commonly used in multiple drug therapy were evaluated using both in vitro culture (cell-free as well as macrophage) system and mouse footpad. No additive effects were obtained in the in vitro system when dapsone was combined with either rifampicin or clofazimine, while a strong antagonism was observed when clofazimine was combined with rifampicin but not with rifabutin. In the mouse footpad system, a strong synergism was obtained when clofazimine was combined with either rifampicin or rifabutin, but significant antagonism was observed with the combination of clofazimine and dapsone.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Rifampin / Rifamicinas / Pruebas de Sensibilidad Microbiana / Clofazimina / Rifabutina / Medios de Cultivo / Dapsona / Interacciones Farmacológicas / Quimioterapia Combinada / Leprostáticos Idioma: Inglés Revista: Indian J Lepr Asunto de la revista: Tropical Medicine Año: 1991 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Rifampin / Rifamicinas / Pruebas de Sensibilidad Microbiana / Clofazimina / Rifabutina / Medios de Cultivo / Dapsona / Interacciones Farmacológicas / Quimioterapia Combinada / Leprostáticos Idioma: Inglés Revista: Indian J Lepr Asunto de la revista: Tropical Medicine Año: 1991 Tipo del documento: Artículo