Demonstration of Mycobacterium leprae specific antigens in leprosy lesions using monoclonal antibodies.
Indian J Lepr
;
1985 Apr-Jun; 57(2): 258-64
Artículo
en Inglés
| IMSEAR
| ID: sea-54570
ABSTRACT
Cryostat sections of dermal lesions from 13 untreated patients of leprosy were studied by indirect immunoperoxidase using monoclonal antibodies (MLO4 & MLO6), defining M. leprae specific antigens. The lymphocytes and macrophages in both the tuberculoid and lepromatous granulomas showed membranous staining with the above antibodies. M. leprae organisms in the lepromatous granulomas and the cells in the section of lymph nodes of patients with tuberculosis, or sections of normal skin or psoriatic lesions did not show any staining with these antibodies. These observations suggest that M. leprae specific antigens are present and expressed on the cells infiltrating the granulomas of leprosy lesions.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Piel
/
Tuberculosis
/
Humanos
/
Técnicas para Inmunoenzimas
/
Lepra
/
Ganglios Linfáticos
/
Anticuerpos Monoclonales
/
Mycobacterium leprae
/
Epítopos
/
Antígenos Bacterianos
Idioma:
Inglés
Revista:
Indian J Lepr
Asunto de la revista:
Tropical Medicine
Año:
1985
Tipo del documento:
Artículo
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