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Identification of sequence similarities between Mycobacterium leprae and the myelin proteolipid protein by computational analysis.
Indian J Lepr ; 1999 Jan-Mar; 71(1): 1-10
Artículo en Inglés | IMSEAR | ID: sea-54775
ABSTRACT
This study was undertaken under the assumption that antigenic mimicry plays a role in the pathogenesis of neuropathy in leprosy, a unique feature among mycobacterial diseases. The SWISS-PROT protein sequence databank was scanned using a computer programme based on an identity matrix algorithm, to identify common amino acid regions between human myelin and mycobacterial proteins. The highlighted motifs were back-tested against a database of MHC-binding peptides (MHCPEP). Of the 28 common sequences between mycobacterial and human myelin proteins, only two were found to yield some matches with MHC-presenting peptides. Both motifs were from M.leprae. The myelin proteolipid protein was the human protein containing the identified similarities. We believe that this theoretical approach can provide a way to predict potentially "mimetic" motifs by search for antigenic regions in protein sequence databases without screening a large number of synthetic peptides.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Proteínas Bacterianas / Programas Informáticos / Humanos / Datos de Secuencia Molecular / Bases de Datos Factuales / Secuencia de Aminoácidos / Homología de Secuencia de Aminoácido / Proteína Proteolipídica de la Mielina / Análisis de Secuencia de Proteína / Mycobacterium leprae Idioma: Inglés Revista: Indian J Lepr Asunto de la revista: Tropical Medicine Año: 1999 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Proteínas Bacterianas / Programas Informáticos / Humanos / Datos de Secuencia Molecular / Bases de Datos Factuales / Secuencia de Aminoácidos / Homología de Secuencia de Aminoácido / Proteína Proteolipídica de la Mielina / Análisis de Secuencia de Proteína / Mycobacterium leprae Idioma: Inglés Revista: Indian J Lepr Asunto de la revista: Tropical Medicine Año: 1999 Tipo del documento: Artículo