Antihepatotoxic effect of beta-carotene on paracetamol induced hepatic damage in rats.
Indian J Exp Biol
;
2005 Apr; 43(4): 351-5
Artículo
en Inglés
| IMSEAR
| ID: sea-55793
ABSTRACT
Enzyme levels of serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) and alkaline phosphatase (ALP) increased following paracetamol induction were significantly lowered due to pretreatment with the beta-carotene (BC). This supplementation reversed the trend inducing a significant decrease in bilirubin and urea levels. Paracetamol administration significantly reduced hepatic glycogen, glutathione (GSH), glutathione-S-transferase (GST), glutathione peroxidase (GPX) and glutathione reductase (GSH-R). Pretreatment of rats with BC significantly increased the enzyme activities. The results suggest hepatoprotective activity of BC.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Ratas
/
Ratas Wistar
/
Analgésicos no Narcóticos
/
Beta Caroteno
/
Modelos Animales de Enfermedad
/
Enfermedad Hepática Inducida por Sustancias y Drogas
/
Hígado
/
Animales
/
Acetaminofén
/
Antioxidantes
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
2005
Tipo del documento:
Artículo
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