Poly (DL-lactide-co-glycolide) microparticles as carriers for antimycobacterial drug rifampicin.
Indian J Exp Biol
;
2000 Sep; 38(9): 887-94
Artículo
en Inglés
| IMSEAR
| ID: sea-55802
ABSTRACT
Poly (DL-lactide-co-glycolide) polymers were investigated as carriers for the first line antitubercular drug rifampicin. Different formulations of PLG microparticles viz. porous, non porous and hardened exhibited sustained release of rifampicin up to 7 weeks in vitro. However, hardened PLG microparticles exhibited the most sustained release in vivo in different organs up to 6 weeks. In case of free rifampicin, release was detected in vivo only up to 48 hr. In addition, no hepatotoxicity was observed on a biochemical basis (levels of SGPT, ALP and total bilirubin) in comparison to control animals. Taken together, these results suggest that polymer encapsulated antitubercular drug rifampicin may serve as an ideal therapeutic approach for treatment of tuberculous infections.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Tamaño de la Partícula
/
Ácido Poliglicólico
/
Polímeros
/
Rifampin
/
Bilirrubina
/
Materiales Biocompatibles
/
Femenino
/
Masculino
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Portadores de Fármacos
/
Sistemas de Liberación de Medicamentos
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
2000
Tipo del documento:
Artículo
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