Autoantigen Ku and its role in multiple cellular processes.
Indian J Exp Biol
;
1997 Dec; 35(12): 1261-72
Artículo
en Inglés
| IMSEAR
| ID: sea-55869
ABSTRACT
Ku is a DNA binding protein composed of 70 and 80 kDa subunits which was discovered as autoantigen in a patient with scleroderma-polymyositis overlap syndrome. Ku can bind to the end of DNA and also to some internal sequences. Ku-autoantigen acts as a potential transcription factor for several RNA polymerase II genes and RNA polymerase I gene. Ku is also associated with DNA-dependent protein kinase and involved in V(D)J recombination and DNA break repair mechanisms. Ku may be involved in replication, helicase activity and cell signaling. Therefore, Ku-autoantigen is a very important cellular factor which plays important role in the multiple cellular processes.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Autoantígenos
/
Factores de Transcripción
/
Humanos
/
Proteínas Nucleares
/
ADN Helicasas
/
Antígenos Nucleares
/
Proteínas de Unión al ADN
/
Reparación del ADN
/
Animales
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
1997
Tipo del documento:
Artículo
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