Evaluation of some newer non-steroidal anti-inflammatory indan-1-acids in various biological systems.
Indian J Exp Biol
;
1992 Jul; 30(7): 583-6
Artículo
en Inglés
| IMSEAR
| ID: sea-56077
ABSTRACT
In line of the effort towards development of some newer indanyl non-steroidal anti-inflammatory agents and providing comprehensive SAR among this class of compounds some significantly active derivatives with low ulcerogenic potential were identified. Dealing with various long chain and branched chain compounds among this series, 3-(5, 6-dimethoxy indan-1-yl) propionic acid, 2-(5, 6-dimethoxy indan-1-yl) propionic acid and 3-(6-methoxy indan-1-yl) propionic acid were observed to have encouraging biological activity. Screening in various animal models of inflammation suggests their longer duration of action and lower ulcerogenic liability.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Dolor
/
Úlcera Péptica
/
Artritis Experimental
/
Ratas
/
Temperatura Corporal
/
Masculino
/
Antiinflamatorios no Esteroideos
/
Ratas Wistar
/
Relación Dosis-Respuesta a Droga
/
Edema
Tipo de estudio:
Estudio diagnóstico
/
Estudios de evaluación
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
1992
Tipo del documento:
Artículo
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