Pattern of enzyme changes in rabbits administered linamarin or potassium cyanide.
Indian J Exp Biol
;
1989 Jun; 27(6): 551-5
Artículo
en Inglés
| IMSEAR
| ID: sea-56156
ABSTRACT
Diseases like tropical ataxic neuropathy and endemic goitre have been reported to have definite correlation with a chronic ingestion of cassava (Manihot esculenta Crantz). The toxicity of cassava has been attributed to its two cyanogenic glycosides, linamarin and lotaustralin. In this study, an attempt has been made to understand the pattern of changes in certain clinically significant enzymes brought about by the chronic administration of sublethal doses of linamarin to rabbits. The profound elevation in rhodanese activity observed in the linamarin and cyanide treated rabbits indicated the attempt of the tissues to detoxify cyanide. That intact linamarin could be hydrolysed in vivo was a significant finding from the study. The mode of toxicity of linamarin was similar to that of cyanide by producing a gradual shift from aerobic to anaerobic metabolism.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Cianuro de Potasio
/
Conejos
/
Sulfurtransferasas
/
Tiosulfato Azufretransferasa
/
Encéfalo
/
Masculino
/
Inactivación Metabólica
/
Beta-Glucosidasa
/
Complejo IV de Transporte de Electrones
/
Cianuros
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
1989
Tipo del documento:
Artículo
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