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Hyperglycaemia in pregnancy: effects on the offspring behaviour with special reference to anxiety paradigms.
Indian J Exp Biol ; 2000 Mar; 38(3): 231-6
Artículo en Inglés | IMSEAR | ID: sea-56157
ABSTRACT
Maternal hyperglycemic effect was studied on the offspring behaviour. Offspring were obtained from diabetic rats by mating a normal father with a diabetic mother (NFDM), diabetic father with normal mother (DFNM) and diabetic father with diabetic mother (DFDM). Rats were rendered diabetic by injecting streptozotocin (STZ, 50 mg/kg i.p.) in citrate buffer. Offspring were subjected to various anxiety parameters including open field exploratory behaviour, elevated plus maze and zero maze behaviours, and the social interaction tests at the age of 8 weeks. The results indicate that offspring of NFDM and DFDM showed anxiogenic activity on the elevated plus maze zero maze and the social interaction test. Offspring of NFDM and DFDM exhibited hyper and emotional activity in the open field behaviour test. The behavioural alterations observed in the offspring were comparable to the behavioural alterations noted in STZ diabetic rat as reported earlier. Further offspring of NFDM and DFDM exhibited mild hyperglycaemia. No significant behavioural alterations in the offspring of DFNM were observed. It may be concluded, that exposure of offspring to diabetic environment in their foetal life can lead to anxiogenic/emotional behaviours in adult life.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Ansiedad / Embarazo en Diabéticas / Ratas / Conducta Social / Conducta Animal / Femenino / Masculino / Embarazo / Aprendizaje por Laberinto / Diabetes Mellitus Experimental Idioma: Inglés Revista: Indian J Exp Biol Año: 2000 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Ansiedad / Embarazo en Diabéticas / Ratas / Conducta Social / Conducta Animal / Femenino / Masculino / Embarazo / Aprendizaje por Laberinto / Diabetes Mellitus Experimental Idioma: Inglés Revista: Indian J Exp Biol Año: 2000 Tipo del documento: Artículo