Protective effect of picroliv, active constituent of Picrorhiza kurrooa, against oxytetracycline induced hepatic damage.
Indian J Exp Biol
;
1997 Dec; 35(12): 1302-5
Artículo
en Inglés
| IMSEAR
| ID: sea-56235
ABSTRACT
Picroliv, the active constituent of P. kurrooa, showed a dose dependent (1.5-12 mg/kg, po for 7 days) hepatoprotective activity against oxytetracycline induced hepatic damage in rat. It increased the number of viable hepatocytes (ex-vivo) significantly. Increase in bile volume and its contents in conscious rat suggests potent anticholestatic property. Picroliv also antagonised alterations in enzyme levels (GOT, GPT, and alkaline phosphatase) in isolated hepatocytes and serum, induced by oxytetracycline (200 mg/kg, i.p.) feeding. Picroliv was more potent than silymarin a known hepatoprotective drug.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Oxitetraciclina
/
Ratas
/
Silimarina
/
Ácido Vanílico
/
Femenino
/
Masculino
/
Extractos Vegetales
/
Cinamatos
/
Glicósidos
/
India
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
1997
Tipo del documento:
Artículo
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