Effect of cyproheptadine on glucose tolerance, serum insulin and structure of pancreatic islets in rats.
Indian J Exp Biol
;
1990 Aug; 28(8): 721-3
Artículo
en Inglés
| IMSEAR
| ID: sea-56281
ABSTRACT
The effect of cyproheptadine (CPH) on glucose tolerance, serum immunoreactive insulin (IRI) and structure of pancreatic islets in albino rats has been studied. Hyperglycemia with glucose intolerance was observed after 10 days of administration of CPH (40 mg/kg, ip). There was insignificant change of fasting IRI after the treatment. Histological studies indicated degranulation and vacuolation of beta cells with enlargement of capillaries. Improvement in blood glucose, glucose tolerance and structure of islets with proliferation of small pancreatic ducts and cell cords were observed 10 days after the withdrawal of CPH.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Ratas
/
Ratas Endogámicas
/
Glucemia
/
Masculino
/
Islotes Pancreáticos
/
Ciproheptadina
/
Gránulos Citoplasmáticos
/
Prueba de Tolerancia a la Glucosa
/
Hiperglucemia
/
Insulina
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
1990
Tipo del documento:
Artículo
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