Comparative interaction of few antihypertensive drugs with cyclosporine-A in rats.
Indian J Exp Biol
;
2007 Jul; 45(7): 638-41
Artículo
en Inglés
| IMSEAR
| ID: sea-56333
ABSTRACT
The maximal endothelial dependent relaxation of isolated aortic rings to cumulative doses of acetylcholine was significantly decreased in the Cyclosporine-A (CSA, 20 mg kg(-1) day(-1)) treated animals compared to olive oil (CSA vehicle) treated control. Administration of antihypertensive drugs like diltiazem, enalapril or propranolol to CSA treated animals augmented the endothelial damage induced by CSA. These drugs also increased the bioavailability of CSA. However, administration of losartan to CSA treated animals produced a significant increase in endothelial dependent relaxation as compared to CSA treated control but did not affect the bioavailability of CSA significantly. The results suggest that losartan is safer compared to other antihypertensives for the treatment of CSA induced hypertension.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Aorta Torácica
/
Propranolol
/
Ratas
/
Aceites de Plantas
/
Masculino
/
Diltiazem
/
Enalapril
/
Acetilcolina
/
Cromatografía Líquida de Alta Presión
/
Ciclosporina
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
2007
Tipo del documento:
Artículo
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