Role of iron and copper during benzene toxicity.
Indian J Exp Biol
;
1998 Mar; 36(3): 283-6
Artículo
en Inglés
| IMSEAR
| ID: sea-56667
ABSTRACT
Role of transition metal ions in expression of benzene toxicity has been suggested. Intraperitoneal administration of benzene to female albino rats daily for 10 days resulted in accumulation of iron in liver nuclei, without any change in copper content. Incubation of hydroquinone (HQ), one of the principal metabolites of benzene with rat liver nuclei resulted in formation of thiobarbituric acid reactive products (TBAR). However, presence of bathocuproine, a copper chelator and EDTA, an iron chelator caused significant inhibition of TBAR release. Thus, the present study revealed that iron accumulation and involvement of copper in nuclear damage induced by HQ.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Ratas
/
Benceno
/
Femenino
/
Masculino
/
Núcleo Celular
/
Depuradores de Radicales Libres
/
Sustancias Reactivas al Ácido Tiobarbitúrico
/
Cobre
/
Hierro
/
Hígado
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
1998
Tipo del documento:
Artículo
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