Release of iron from haemoglobin--a possible source of free radicals in diabetes mellitus.
Indian J Exp Biol
;
1999 Feb; 37(2): 190-2
Artículo
en Inglés
| IMSEAR
| ID: sea-56902
ABSTRACT
Increased blood glucose in diabetes mellitus stimulates nonenzymatic glycosylation of several proteins, including haemoglobin. Although iron is tightly bound to haemoglobin, it is liberated under specific circumstances yielding free reactive iron. Studies with purified haemoglobin from normal individuals and diabetic patients revealed that concentration of free iron was significantly higher in the latter cases and increased progressively with extent of the disease. In vitro glycosylation of haemoglobin also led to increase in release of iron from protein. This increase in free iron, acting as a Fenton reagent, might produce free radicals, which, in turn might be causing oxidative stress in diabetes.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Humanos
/
Hemoglobina Glucada
/
Hemoglobinas
/
Estudios de Casos y Controles
/
Estrés Oxidativo
/
Diabetes Mellitus
/
Radicales Libres
/
Hierro
Tipo de estudio:
Estudio observacional
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
1999
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS