Relative role of B and T lymphocytes in pathogenesis of a murine herpes virus.
Indian J Exp Biol
;
1992 Aug; 30(8): 690-5
Artículo
en Inglés
| IMSEAR
| ID: sea-57138
ABSTRACT
Pathogenesis of a murine herpes virus was investigated in inbred strains (BALB/c, CBA, AKR and C57BL/10) of mice. After intranasal inhalation, virus was found to replicate primarily in the lungs, followed by haematogenous spread to the target organs (adrenal glands and ganglia). AKR (H-2k) were found to be most susceptible to virus infection while CBA (H-2k) mice appeared to be relatively resistant. Infection of B-cell depleted BALB/c mice resulted in detection of lower lung virus titres in B-cell depleted animals as compared to normal intact mice. Moreover, 3 of 12 normal mice in untreated group died of virus infection while deaths did not occur in the B-cell depleted group. Results of T-cell subset depletion experiments in BALB/c mice revealed maximum mortality in the group depleted of both Lyt-2+ and L3T4+ subpopulations. Infectious virus titres were also higher in lungs of T-cell depleted animals.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Femenino
/
Linfocitos B
/
Subgrupos de Linfocitos T
/
Depleción Linfocítica
/
Infecciones por Herpesviridae
/
Herpesviridae
/
Animales
/
Ratones
/
Ratones Endogámicos
Tipo de estudio:
Estudio de etiología
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
1992
Tipo del documento:
Artículo
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