Expression and functional activity of receptor-Ck in mononuclear cells of a homozygous hypercholesterolemic family.
Indian Heart J
;
2002 Jan-Feb; 54(1): 88-90
Artículo
en Inglés
| IMSEAR
| ID: sea-5714
ABSTRACT
The study was addressed to explore the expression and functional activity of a novel cholesterol-specific cell surface receptor-Ck in a typical homozygous familial hypercholesterolemic family. Functional activity of receptor-Ck was characterized by its ability to downregulate Bcl-2 gene expression through a 47 kDa factor having an affinity for the sterol-regulatory element in the promoter region of this gene. The result of such a study revealed normal expression and functional activity of receptor-Ck accompanied by a lack of Apolipoprotein B-specific low-density lipoprotein receptor gene expression in the mononuclear cells derived from these patients. On the basis of these results, it is tempting to speculate that receptor-Ck may be involved in the maintenance of cellular cholesterol homeostasis observed in homozygous familial hypercholesterolemic patients.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Apolipoproteínas B
/
Factores de Transcripción
/
Humanos
/
Masculino
/
Receptores de LDL
/
Regulación hacia Abajo
/
Regulación de la Expresión Génica
/
Salud de la Familia
/
Adolescente
/
Receptores de Lipoproteína
Idioma:
Inglés
Revista:
Indian heart j
Año:
2002
Tipo del documento:
Artículo
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