Membrane damaging potential of photosensitized riboflavin.
Indian J Exp Biol
;
1991 Sep; 29(9): 818-22
Artículo
en Inglés
| IMSEAR
| ID: sea-57324
ABSTRACT
Riboflavin upon exposure to UV and visible radiations has been shown to produce active oxygen species. The present work deals with erythrocyte membrane as model system to study the damaging potential of photosensitized riboflavin. Membrane preparations (2.5 mg protein/ml) following exposure to sunlight in presence of riboflavin for different time intervals revealed significant inhibition of ATPases, p-nitrophenyl phosphatase and acetylcholinesterase. Considerable increase in lipid peroxidation was caused by the photosensitized riboflavin. Quenching studies using specific scavengers indicated remarkable inhibition. The production and identification of reactive oxygen species by photosensitized riboflavin and their possible involvement in membrane damaging effect has been discussed.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Oxígeno
/
Fotoquímica
/
Riboflavina
/
Humanos
/
Membrana Eritrocítica
/
Radicales Libres
/
Luz
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
1991
Tipo del documento:
Artículo
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