Characteristics and physiological role of surfactant-like particles secreted by entrocytes.
Indian J Exp Biol
;
2006 Jul; 44(7): 519-25
Artículo
en Inglés
| IMSEAR
| ID: sea-57413
ABSTRACT
Intestinal epithelium secretes novel unilamellar membranes having characteristics similar to lung surfactants and thus has been named Surfactant-like particles (SLP). The chemical analysis of the membranes revealed cholesterol/phospholipid molar ratio of 0.68-0.78, which is much distinct from that of the underlying microvillus membranes (1.34-1.49). The membrane contains 4-6 proteins with a molar weight of 30-120 kDa and is enriched with alkaline phosphatase, contains low amounts of disaccharidases but no Na+, K(+)-ATPase activity. The secretion of SLP is stimulated by fat feeding. Chronic ethanol ingestion also induces the formation of SLP in rat intestine. A number of physiological functions have been attributed to SLP, which include (i) as a protective lubricant in intestinal lumen, (ii) a role in triacylglycerol transport, (iii) as a vehicle for the transport of luminal proteins into blood, (iv) as a stratum for the adhesion of microorganisms in intestinal lumen, and (v) a role in trans-signalling mechanism across the basolateral surface of enterocytes.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Fosfolípidos
/
Tensoactivos
/
Humanos
/
Grasas de la Dieta
/
Enterocitos
/
Fosfatasa Alcalina
/
Membranas Intracelulares
/
Lipoproteínas
/
Animales
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
2006
Tipo del documento:
Artículo
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