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Role of pure and biologically active amoebal RNA in assessment of lymphokines: a report of 55 ALA cases.
Indian J Exp Biol ; 1992 Aug; 30(8): 743-4
Artículo en Inglés | IMSEAR | ID: sea-57488
ABSTRACT
Amoebic liver abscess cases (55) were assessed for release of lymphokines (LMIF) using pure and biologically active amoebal RNA of axenic Entamoeba histolytica (NIH 200) obtained with cesium chloride centrifugation. Lymphokines released by T lymphocytes in response to both amoebal RNA and whole amoebic lysate (WAL) were tested by leukocyte migration inhibition test (LMIT) on blood samples from amoebic liver abscess cases. A significant increase was observed in the release of lymphokine and 100% positivity was observed with amoebal RNA compared to whole amoebic extract with a positivity of only 78%. The difference between means leukocyte migration inhibition of the above two with regards to release of lymphokine was highly significant (P less than 0.001). This shows that patients had high degree of leukocyte sensitization to amoebal RNA of E. histolytica compared to whole amoebic lysate. These findings suggest that the amoebal RNA plays an important role as a potent antigen in the elicitation of cell mediated immune responses in amoebic liver abscess cases.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Femenino / Humanos / Masculino / Linfocitos / ARN Protozoario / Linfocinas / Adulto / Entamoeba histolytica / Inmunidad Celular / Absceso Hepático Amebiano Idioma: Inglés Revista: Indian J Exp Biol Año: 1992 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Femenino / Humanos / Masculino / Linfocitos / ARN Protozoario / Linfocinas / Adulto / Entamoeba histolytica / Inmunidad Celular / Absceso Hepático Amebiano Idioma: Inglés Revista: Indian J Exp Biol Año: 1992 Tipo del documento: Artículo