Effect of piperine on pentobarbitone induced hypnosis in rats.
Indian J Exp Biol
;
1990 May; 28(5): 486-7
Artículo
en Inglés
| IMSEAR
| ID: sea-57642
ABSTRACT
Piperine (1-peperoyl piperidine), a major alkaloid isolated from Piper nigrum Linn, potentiated pentobarbitone sleeping time in dose dependant manner, with peak effect at 30 min. Blood and brain pentobarbitone levels were higher in piperine treated animals. Piperine treatment in rats, treated chronically with phenobarbitone, significantly potentiated pentobarbitone sleeping time, as compared to the controls. There was no alteration in barbital sodium sleeping time. It is possible that, piperine inhibits liver microsomal enzyme system and thereby potentiates the pentobarbitone sleeping time.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Pentobarbital
/
Piperidinas
/
Ratas
/
Sueño
/
Masculino
/
Microsomas Hepáticos
/
Sinergismo Farmacológico
/
Alcaloides
/
Benzodioxoles
/
Alcamidas Poliinsaturadas
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
1990
Tipo del documento:
Artículo
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