Effect of selective muscarinic receptor agonists and antagonists on active-avoidance learning acquisition in rats.
Indian J Exp Biol
;
1991 Feb; 29(2): 136-9
Artículo
en Inglés
| IMSEAR
| ID: sea-57848
ABSTRACT
Effect of some selective muscarinic receptor agonists and antagonists was investigated on learning acquisition in an active-avoidance paradigm in rats which records an anticipatory conditioned avoidance apart from the classical conditioned avoidance response. The muscarinic M1 agonists, arecholine, pilocarpine and McN-A-343, facilitated learning acquisition, which was attenuated by the selective M1 antagonist, pirenzepine. On the other hand, M2 receptor agonist, carbachol, and physostigmine, induced a dose-related dual response, with lower doses retarding and higher doses facilitating the learning acquisition. The former effect was attenuated by gallamine, a muscarinic M2 antagonist, while the latter response was inhibited by pirenzepine, indicating that these putative M2 receptor agonist lose their receptor specificity on dose increment. The selective M2 receptor antagonists, gallamine and AF-DX 116, facilitated learning acquisition, which was inhibited by pirenzepine and the acetylcholine synthesis inhibitor hemicholinium. The results support the cholinergic hypothesis of learning and memory and indicate that M1 receptor agonists and M2 receptor antagonists are likely to prove beneficial in memory deficits. The data also indicates that the clinical dose of some drugs, like physostigmine, needs to be carefully established for optimum therapeutic benefit.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Parasimpaticomiméticos
/
Ratas
/
Ratas Endogámicas
/
Reacción de Prevención
/
Femenino
/
Masculino
/
Receptores Muscarínicos
/
Antagonistas Muscarínicos
/
Aprendizaje
/
Animales
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
1991
Tipo del documento:
Artículo
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