Antimutagenic activity of Terminalia chebula (myroblan) in Salmonella typhimurium.
Indian J Exp Biol
;
1992 Apr; 30(4): 339-41
Artículo
en Inglés
| IMSEAR
| ID: sea-57884
ABSTRACT
Antimutagenicity of water and chloroform extracts of dried myroblan Terminalia chebula was determined against two direct acting mutagens, sodium azide and 4-nitro-o-phenylenediamine (NPD) in strains TA100 and TA1535, and TA97a and TA98 of Salmonella typhimurium respectively and S9-dependent mutagen 2-aminofluorene (2-AF) in TA97a, TA98 and TA100 strains. Water extract reduced NPD as well as 2-AF induced his+ revertants significantly but did not have any perceptible effect against sodium azide included his+ revertants in TA100 and TA1535 strains of S. typhimurium. The pre-incubation studies, where the extract was incubated at 37 degrees C for 30 min with the said mutagen prior to plating, enhanced the inhibitory effect. Autoclaving the water extract reduced the inhibitory effect but the reduction in the effect was not significant. No inhibitory effect was observed in any of the strains and against any of the test mutagens with chloroform extract.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Plantas Medicinales
/
ADN
/
Extractos Vegetales
/
Cloroformo
/
Relación Dosis-Respuesta a Droga
/
Pruebas de Mutagenicidad
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
1992
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS