Lowering of intraocular pressure by topical application of Daucus carota seed extract in rabbits.
Indian J Exp Biol
; 2008 Jul; 46(7): 541-6
Article
en En
| IMSEAR
| ID: sea-58066
In normotensive rabbits topical application of Daucus carota seed extract at the concentration of 0.3, 0.6 and 1.2% resulted in mean IOP reduction of 19.33. 23.20 and 25.61% respectively from baseline. As no significant difference was observed between the change in IOP in 0.6 and 1.2% extract treated groups, 0.6% concentration was chosen for further evaluation in rabbits with experimentally elevated IOP. In water loaded rabbits, maximum mean IOP reduction with 0.6% extract was 29.39%, which was comparable to pilocarpine. In steroid pretreated rabbits, maximum mean IOP reduction was 30.27% from baseline, which was significantly higher than pilocarpine. The extract showed a comparatively slower onset of action however, the duration of action was comparable to pilocarpine in all the experimental models.
Texto completo:
1
Índice:
IMSEAR
Idioma:
En
Revista:
Indian J Exp Biol
Año:
2008
Tipo del documento:
Article