Effect of masheri, a pyrolysed tobacco product on carcinogen metabolizing enzymes.
Indian J Exp Biol
;
1989 Aug; 27(8): 692-4
Artículo
en Inglés
| IMSEAR
| ID: sea-58168
ABSTRACT
Studies on the modulation of the carcinogen metabolizing enzymes on treatment with masheri extract (ME) and benzo (a) pyrene (B (a)P), were carried out in male Sprague Dawley rats (12 weeks old) fed a nutritionally adequate standard diet. Injection (ip) of ME and B (a) P at 3/4 LD50 dose given in 3 doses at 24 hr interval increased the phase I activating enzymes, viz. cytochrome P-450, benzo (a) pyrene hydroxylase and benzphetamine demethylase while both ME and B (a) P significantly depleted glutathione content and decreased glutathione-S transferase activity. Furthermore, the same treatment of ME and B (a) P significantly depleted the hepatic vitamin A pool while a concommittant increase in vitamin C content was observed.
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IMSEAR (Asia Sudoriental)
Asunto principal:
Oxidorreductasas N-Desmetilantes
/
Ratas
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Ratas Endogámicas
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Benzo(a)pireno
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Masculino
/
Extractos Vegetales
/
Hidrocarburo de Aril Hidroxilasas
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Benzopireno Hidroxilasa
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Sistema Enzimático del Citocromo P-450
/
Hígado
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
1989
Tipo del documento:
Artículo
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