Immunomodulatory role of thyroid hormones: in vitro effect of tetraiodothyronine (T4) on mitogen induced blastogenic response of lymphocytes.
Indian J Exp Biol
;
1990 Apr; 28(4): 322-5
Artículo
en Inglés
| IMSEAR
| ID: sea-58302
ABSTRACT
An attempt was made to find out the immunomodulatory role of thyroid hormone, tetraiodothyronine (T4), and its effect on in vitro mitogen induced blastogenesis. Human peripheral blood lymphocytes (PBL) were subjected to phytohaemagglutinin (PHA) concanavalin-A (Con. A) and pokeweed mitogen (PWM) in presence or absence of T4. Basal blastogenic response was significantly enhanced in dose related manner by T4. PHA and Con.A induced response was depressed significantly (r = -0.975 and r = -0.945) whereas less than 50 ng T4 in presence of PHA showed mild stimulation. On the other hand, PWM induced response in presence of T4 was enhanced significantly in dose related manner.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Fitohemaglutininas
/
Mitógenos de Phytolacca americana
/
Tiroxina
/
Humanos
/
Activación de Linfocitos
/
División Celular
/
Células Cultivadas
/
Concanavalina A
/
Adulto
/
Mitógenos
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
1990
Tipo del documento:
Artículo
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