Morphine-like activity of some N-substituted amides of met-enkephalin.
Indian J Exp Biol
;
1989 Sep; 27(9): 826-8
Artículo
en Inglés
| IMSEAR
| ID: sea-58304
ABSTRACT
Opioid activity of a homologous series of met-enkephalin alkylamides was analysed. In guinea pig ileum test, the hexylamide derivative was most active, whereas the isopropylamide derivative was most potent in analgesia test. The results suggest that structural changes of this type at the C-terminus of the pentapeptide improve the opioid activity.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Encefalina Metionina
/
Química
/
Fenómenos Químicos
/
Amidas
/
Cobayas
/
Íleon
/
Animales
/
Morfina
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
1989
Tipo del documento:
Artículo
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