Testicular toxicity of di-n-butyl phthalate in adult rats: effect on marker enzymes of spermatogenesis.
Indian J Exp Biol
;
1990 Jan; 28(1): 67-70
Artículo
en Inglés
| IMSEAR
| ID: sea-58684
ABSTRACT
Di-n-butyl phthalate (DBP) was administered to adult male rats by gavage at the doses of 250, 500 and 1000 mg/kg body weight/day for 15 days. A significant decrease in epididymal spermatozoa counts was observed at 500 and 1000 mg/kg doses of DBP. The activity of sorbitol dehydrogenase was found to be significantly decreased while that of lactate dehydrogenase, gamma-glutamyl transpeptidase, beta-glucuronidase, and glucose-6-phosphate dehydrogenase, significantly increased in the animals exposed to 500 and 1000 mg/kg of DBP. Decrease in the activity of acid phosphatase was also observed at all dose levels. Histopathological studies revealed marked degeneration of seminiferous tubules, further confirming testicular toxicity of DBP. The results suggest that testicular atrophy caused by DBP is associated with an alteration in the activities of enzymes related with specific events of spermatogenesis.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Ácidos Ftálicos
/
Ratas
/
Ratas Endogámicas
/
Atrofia
/
Espermatogénesis
/
Testículo
/
Masculino
/
Dibutil Ftalato
/
Animales
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
1990
Tipo del documento:
Artículo
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