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Early and transient induction of nitric oxide (NO) in infectious bursal disease virus infection is T-cell dependent: a study in cyclosporin-A treated chicken-model.
Indian J Exp Biol ; 2005 Feb; 43(2): 192-6
Artículo en Inglés | IMSEAR | ID: sea-58818
ABSTRACT
The level of nitric oxide (NO) in the supernatants of mitogen (PHA) stimulated lymphocyte cultures from infectious bursal disease (IBD) virus infected T-cell suppressed and immune competent chickens was monitored. The immune competent chickens when infected with IBD virus showed 4-6 folds increased levels of NO as compared to uninfected chickens. The levels of NO in T-cell suppressed chickens were comparable to uninfected control chickens, in spite of markedly increased hemorrhage suggesting that the muscular hemorrhage observed in IBD in not solely and directly related with NO production. The immune suppressed chickens that did not induce NO production after IBD virus infection showed more severe lesions and supported enhanced virus replication. Taken together it may be suggested that NO production after IBD virus infection, may exert antiviral effect since the immune-suppressed chickens that failed to induce NO showed more severe disease and higher magnitude of virus replication, but does not seem to correlate with the hemorrhagic lesions which in fact may be as a result of the net outcome of various host-factors and the determinants responsible for virus virulence and virus clearance.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Linfocitos T / Pollos / Ciclosporina / Infecciones por Birnaviridae / Virus de la Enfermedad Infecciosa de la Bolsa / Modelos Animales de Enfermedad / Inmunosupresores / Animales / Óxido Nítrico Tipo de estudio: Estudio pronóstico Idioma: Inglés Revista: Indian J Exp Biol Año: 2005 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Linfocitos T / Pollos / Ciclosporina / Infecciones por Birnaviridae / Virus de la Enfermedad Infecciosa de la Bolsa / Modelos Animales de Enfermedad / Inmunosupresores / Animales / Óxido Nítrico Tipo de estudio: Estudio pronóstico Idioma: Inglés Revista: Indian J Exp Biol Año: 2005 Tipo del documento: Artículo