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Effect of inactivated viral vaccines (human) on frequency of micronuclei in bone marrow erythrocytes of mice.
Indian J Exp Biol ; 1991 Jul; 29(7): 683-5
Artículo en Inglés | IMSEAR | ID: sea-58823
ABSTRACT
Cytogenetic effects of the two inactivated viral vaccines (polio and antirabies) were studied in adult male mice by the micronucleus test. Polio salk vaccine did not induce micronuclei formation at both human (0.5 ml) and 1/5th human doses. Antirabies vaccine induced micronuclei in poly and total erythrocytes only at human dose of 2 ml. Beta-propiolactone (BPL) induced micronuclei at higher dose of 5.7 mg, but not at 0.57 mg (approximate concentration present in 2 ml of rabies vaccine). The P/N ratio was not affected in vaccinated and BPL inoculated animals. Antirabies vaccine induced micronuclei percentage was more than the BPL value.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Propiolactona / Médula Ósea / Masculino / Células de la Médula Ósea / Vacuna Antipolio de Virus Inactivados / Vacunas Antirrábicas / Pruebas de Micronúcleos / Vacunas de Productos Inactivados / Eritrocitos / Animales Idioma: Inglés Revista: Indian J Exp Biol Año: 1991 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Propiolactona / Médula Ósea / Masculino / Células de la Médula Ósea / Vacuna Antipolio de Virus Inactivados / Vacunas Antirrábicas / Pruebas de Micronúcleos / Vacunas de Productos Inactivados / Eritrocitos / Animales Idioma: Inglés Revista: Indian J Exp Biol Año: 1991 Tipo del documento: Artículo