Effect of graded doses of naloxone on renal function in canine hemorrhagic shock.
Indian J Exp Biol
;
1992 Apr; 30(4): 347-9
Artículo
en Inglés
| IMSEAR
| ID: sea-58848
ABSTRACT
All the parameters of renal function (inulin clearance, para amino hippuric acid clearance and urine flow) which were depressed during experimentally induced hemorrhagic shock in dogs improved significantly in addition to improvement in mean arterial pressure (MAP) after bolus administration (iv) of 1 or 2 mg/kg naloxone. A smaller dose (0.5 mg/kg) of naloxone, however, did not improve the renal function. Even renal arterial injection of the same dose of naloxone showed no improvement in the renal function. In both these cases the improvement in the MAP was significantly less as compared to other groups of animals which received 1 or 2 mg/kg naloxone. It may be concluded that (a) naloxone at doses of 1 or 2 mg/kg improved the renal function by improving MAP and (b) naloxone has no direct action on renal vasculature.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Ácido p-Aminohipúrico
/
Choque Hemorrágico
/
Micción
/
Presión Sanguínea
/
Femenino
/
Masculino
/
Perros
/
Relación Dosis-Respuesta a Droga
/
Insulina
/
Riñón
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
1992
Tipo del documento:
Artículo
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