Effects of calcium on phthalocyanine sensitized photohemolysis.
Indian J Exp Biol
;
1998 Feb; 36(2): 152-6
Artículo
en Inglés
| IMSEAR
| ID: sea-58919
ABSTRACT
Influence of divalent Ca2+ ions in sulphonated chlorophthalocyanine (ClAlPcS2) induced photohemolysis in rabbit red blood cells has been investigated. Loading of excess Ca2+ to ClAlPcS2 sensitized RBC suspension enhanced hemolysis in a concentration dependent manner. Protein kinase C (PKC) inhibitor chlorpromazine and cation chelator EDTA reduced Ca2+ enhanced photohemolysis. Photohemolysis increased with calcium channel blockers diltiazem and nifidipine. Enhancement in photohemolysis by Ca2+ ions can arise either by its ability to liberate Fe2+ bound to phosphatidylserine or by stimulation of PKC. Inability of calcium channel blockers to prevent Ca2+ influx following photodynamic treatment of red blood cells suggest nonspecific leakage rather than involvement of Ca2+ channels in erythrocytes.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Conejos
/
Cinética
/
Bloqueadores de los Canales de Calcio
/
Clorpromazina
/
Calcio
/
Ácido Egtácico
/
Fármacos Fotosensibilizantes
/
Eritrocitos
/
Hemólisis
/
Indoles
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
1998
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS