Influence of exogenous thymidine on killing and mutation of Chinese hamster V-79 cells by X-rays, ultraviolet light and N-methyl-N'-nitro-N-nitrosoguanidine.
Indian J Exp Biol
;
1989 May; 27(5): 437-41
Artículo
en Inglés
| IMSEAR
| ID: sea-58996
ABSTRACT
V-79 cells when exposed to thymidine (5 micrograms/ml) in growth medium after treatment with X-rays, UV light and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), responded differently depending upon the agent. For treatment with X-rays and UV light, only induction of mutation was potentiated, but for MNNG treatment, both killing and mutation induction were potentiated. The increase in killing of MNNG exposed cells could be reversed by simultaneous addition of deoxycytidine with thymidine, but, for all the three mutagenic treatments, enhancement in mutation induction could not be suppressed by deoxycytidine.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Timidina
/
Rayos Ultravioleta
/
Masculino
/
Línea Celular
/
Supervivencia Celular
/
Cricetulus
/
Cricetinae
/
Animales
/
Metilnitronitrosoguanidina
/
Mutación
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
1989
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS