Pathogenesis of cerebral malaria.
Indian J Exp Biol
;
1991 Mar; 29(3): 267-71
Artículo
en Inglés
| IMSEAR
| ID: sea-59282
ABSTRACT
Plasmodium knowlesi infected rhesus monkeys were employed for investigating brain tissue damage in experimentally induced cerebral malaria. Light microscopic studies revealed parasitic infiltration of virtually all the regions of CNS. Electron microscopic observations confirmed the light microscopic findings. These studies further revealed the presence of macrophages in the blood vessels of infected monkeys. In conclusion, the pathogenesis of cerebral malaria seems to be an outcome of a typical triad consisting of (1) mechanical obstruction of the blood capillaries by parasitized RBCs; (2) biochemical events, involving free radicals, and (3) immunological dysfunction.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Encefalopatías
/
Microscopía Electrónica
/
Animales
/
Macaca mulatta
/
Malaria
Tipo de estudio:
Estudio de etiología
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
1991
Tipo del documento:
Artículo
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