Distribution of mercury and evaluation of testicular steroidogenesis in mercuric chloride and methylmercury administered rats.
Indian J Exp Biol
;
1990 Aug; 28(8): 746-51
Artículo
en Inglés
| IMSEAR
| ID: sea-59285
ABSTRACT
Intraperitoneal administration of methylmercury chloride (MMC) and mercuric chloride (MC) to male rats in doses of 5, 10 micrograms MMC/kg or 50, 100 micrograms MC/kg for 90 days induced cellular disintegration of Leydig cells which was conspicuous on day 30 and onwards in the exposed groups. Progressive degeneration of Leydig cells and decrease in their nuclear diameter and population were associated with gradual increase in deposition of mercury. Gradual diminution of 3 beta-hydroxy-delta 5-steroid dehydrogenase activity in Leydig cells after MMC or MC treatment was correlated with different structural deformations of the cells over 90 days. Moreover, a significant decrease in serum testosterone levels by day 90 confirmed steroidogenic impairment after MMC or MC treatment.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Ratas
/
Testículo
/
Testosterona
/
Masculino
/
Núcleo Celular
/
3-Hidroxiesteroide Deshidrogenasas
/
Células Intersticiales del Testículo
/
Animales
/
Cloruro de Mercurio
/
Compuestos de Metilmercurio
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
1990
Tipo del documento:
Artículo
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