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Effect of CDRI-85/287, a potent antiimplantation agent on uterine endometrial dimensions and peroxidase levels in rat.
Indian J Exp Biol ; 1998 May; 36(5): 464-9
Artículo en Inglés | IMSEAR | ID: sea-59350
ABSTRACT
CDRI compound 85/287 a potent estrogen antagonist and antiimplantation agent in rat was studied to elucidate its mechanism of action. In ovariectomized rats 85/287 treatment antagonized estrogen stimulated uterine volume density, eosinophil leucocyte infiltration, stromal mitotic cell number and peroxidase activity. In parallel experiments in pregnant rats, uterine peroxidase activity also decreased significantly as compared to controls on day 5 post-coitum. The results show that 85/287 exerts its antiimplantation activity by inhibition of responses to estradiol action.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Implantación del Embrión / Peroxidasas / Piperidinas / Ratas / Benzopiranos / Femenino / Embarazo / Ratas Sprague-Dawley / Endometrio / Antagonistas de Estrógenos Idioma: Inglés Revista: Indian J Exp Biol Año: 1998 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Implantación del Embrión / Peroxidasas / Piperidinas / Ratas / Benzopiranos / Femenino / Embarazo / Ratas Sprague-Dawley / Endometrio / Antagonistas de Estrógenos Idioma: Inglés Revista: Indian J Exp Biol Año: 1998 Tipo del documento: Artículo