Enhancer aided in vitro permeation of atenolol and prazosin hydrochloride through mice skin.
Indian J Exp Biol
;
2001 Jan; 39(1): 47-51
Artículo
en Inglés
| IMSEAR
| ID: sea-59413
ABSTRACT
Effect of penetration enhancers were studied on the permeation of antihypertensive drugs prazosin hydrochloride and atenolol through full thickness skin of swiss albino mice. Atenolol was delivered to skin from saturated alcoholic solution containing 5% of 1-decanol and alcohol alone, while prazosin hydrochloride was saturated in dimethyl formamide(DMF, 5% v/v in water) and dimethyl sulfoxide(DMSO, 5% v/v in water). Atenolol permeation was augmented significantly in decanolic solution and also in pure alcohol. In case of prazosin hydrochloride, significant enhancement of permeation was shown by DMSO but not by DMF.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Atenolol
/
Absorción Cutánea
/
Administración Cutánea
/
Prazosina
/
Dimetilsulfóxido
/
Dimetilformamida
/
Etanol
/
Alcoholes Grasos
/
Animales
/
Ratones
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
2001
Tipo del documento:
Artículo
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