Your browser doesn't support javascript.
loading
Inflammatory responses induced by substance P in rat paw.
Indian J Exp Biol ; 1990 Oct; 28(10): 946-8
Artículo en Inglés | IMSEAR | ID: sea-59419
ABSTRACT
Substance P (SP) injection in the plantar region of rat hind paw caused a dose related inflammation, which reached a peak within 10 min of injection and declined after 60 min. Low doses (0.25-0.063 mg/kg) of SP-antagonists like (D-Pro2, D-Trp7,9)-SP and (D-Pro2, D-Phe7, D-Trp9)-SP pretreatment significantly inhibited the SP induced paw oedema, while higher doses (0.5-1 mg/kg) showed agonistic effects. Pretreatment with diphenhydramine alone or along with low doses of SP-antagonists was highly significant in blocking this inflammation, the latter combination being more effective than the former. Pretreatment with acute capsaicin produced a synergestic effect on SP induced paw oedema, while pretreatment with chronic capsaicin significantly inhibited this SP induced paw oedema. The results indicate involvement of histamine and possible therapeutic importance of capsaicin in SP mediated inflammatory type of responses.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Ratas / Ratas Endogámicas / Femenino / Masculino / Capsaicina / Sustancia P / Antiinflamatorios no Esteroideos / Liberación de Histamina / Inflamación / Animales Idioma: Inglés Revista: Indian J Exp Biol Año: 1990 Tipo del documento: Artículo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Ratas / Ratas Endogámicas / Femenino / Masculino / Capsaicina / Sustancia P / Antiinflamatorios no Esteroideos / Liberación de Histamina / Inflamación / Animales Idioma: Inglés Revista: Indian J Exp Biol Año: 1990 Tipo del documento: Artículo