Pathogenesis of wasting disease after cyclophosphamide treatment of neonatal mice.
Indian J Exp Biol
;
1992 Jan; 30(1): 1-4
Artículo
en Inglés
| IMSEAR
| ID: sea-59613
ABSTRACT
Cyclophosphamide is a potent immunosuppressive agent and is being widely used in organ transplantation. The effects of this anti-rejection drug on lymphoid organs are poorly understood. Newborn Swiss mice injected with various doses of cyclophosphamide suffered from wasting disease at 4 weeks post treatment. The incidence of wasting disease was dose dependent. Haematological picture of the wasting animals revealed leukocytosis of variable degree. Lymphocyte/granulocyte ratio was not inhibited. The cyclophosphamide treatment caused shrinkage of lymphoid organs. Bone marrow showed degeneration of haematopoietic cells. The failure to sustain lymphopoiesis by the potential lymphoid sites following cyclophosphamide treatment and the associated immunological insufficiency resulted in the fatal wasting disease.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Bazo
/
Timo
/
Peso Corporal
/
Médula Ósea
/
Ciclofosfamida
/
Relación Dosis-Respuesta a Droga
/
Enfermedad Injerto contra Huésped
/
Leucocitosis
/
Ganglios Linfáticos
/
Animales
Tipo de estudio:
Estudio de etiología
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
1992
Tipo del documento:
Artículo
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