Effect of honey on carbamazepine kinetics in rabbits.
Indian J Exp Biol
;
2002 May; 40(5): 560-3
Artículo
en Inglés
| IMSEAR
| ID: sea-59619
ABSTRACT
The study was undertaken to determine the effect of honey on carbamazepine kinetics in rabbits. The study was done on three occasions in each animal. Study 1 was carried out after single dose administration of carbamazepine (80 mg/kg, po), along with saline (2.34 ml/kg, po). After a wash out period of one week, the second study was carried out by co-administration of carbamazepine with honey (2.34ml/kg, po). After this, the animals continued to receive honey (2.34ml/kg, po), once daily, for 7 days. On the eighth day of honey treatment, the carbamazepine kinetics was studied again. Pharmacokinetic analysis revealed that single as well as multiple dose honey treatment showed a significant decrease in area under the plasma time concentration curve (AUC) when compared with saline treated control. A significant increase in the clearance (CL/F) rate of carbamazepine was observed only after multiple dose honey treatment. Both single and multiple dose honey treatment did not show any significant effect on other pharmacokinetic parameters like t1/2, Cmax, Tmax and Vd when compared with saline treated group. Data thus obtained suggested that honey decreases the bioavailability of carbamazepine.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Conejos
/
Carbamazepina
/
Interacciones Alimento-Droga
/
Área Bajo la Curva
/
Semivida
/
Miel
/
Animales
/
Anticonvulsivantes
Tipo de estudio:
Estudio pronóstico
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
2002
Tipo del documento:
Artículo
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