Differential effect of cordycepin on S and G2 phases of cell cycle in plasmodia of Physarum polycephalum Schw.
Indian J Exp Biol
;
1991 Sep; 29(9): 801-4
Artículo
en Inglés
| IMSEAR
| ID: sea-59642
ABSTRACT
Effect of pulse treatments of cordycepin, an analog of adenosine, on S and G2 phases of the cell cycle of the mitotically synchronous plasmodia of Physarum polycephalum has been studied. Various concentrations of the drug (50-200 micrograms ml-1) were found to be effective in delaying mitosis by several hours in both the phases. However, there was a significant increase in mitotic delay in those treated during G2. It is suggested that this extra delay during G2 could be due to the transcriptive level inhibition of specific RNA types, such as that of tubulins, whose gene activity is cell cycle regulated and turned on during G2 in Physarum, or alternatively because of a deficiency for ATP and the consequent inhibition of events such as mitotic spindle assembly and phosphorylation of histones.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Desoxiadenosinas
/
Fase G2
/
Fase S
/
Physarum polycephalum
/
Animales
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
1991
Tipo del documento:
Artículo
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