In vivo effects of acetaminophen on rat RBC and role of vitamin E.
Indian J Exp Biol
;
1995 Apr; 33(4): 269-71
Artículo
en Inglés
| IMSEAR
| ID: sea-59756
ABSTRACT
Non-therapeutic toxic dose (250 mg/kg) of acetaminophen (paracetamol), in vivo to albino rats significantly decreased red cell reduced glutathione (GSH) content and activity of (Na+, K+)-ATPase enzyme, whereas osmotic fragility (O.F.) was increased. However, no change was observed in the activity of glutathione reductase (GR) after acetaminophen treatment, while acetaminophen plus vitamin E treated rats showed significant increase in GR activity. Supplementation of vitamin E to the drug treated rats effectively brought the GSH content, (Na+, K+)-ATPase activity and O.F. back to almost normal. The results suggest that acetaminophen toxic dose treatment induces metabolic and membranal alterations making red cells prone to hemolysis, while vitamin E which is an antioxidant shows its ameliorating role to these changes.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Ratas
/
Vitamina E
/
Masculino
/
Analgésicos no Narcóticos
/
Eritrocitos
/
Animales
/
Acetaminofén
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
1995
Tipo del documento:
Artículo
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