Effects of plant extract Centella asiatica (Linn.) on cold restraint stress ulcer in rats.
Indian J Exp Biol
;
1992 Oct; 30(10): 889-91
Artículo
en Inglés
| IMSEAR
| ID: sea-59851
ABSTRACT
Extract of C. asiatica (Linn.) inhibited significantly gastric ulceration induced by cold and restraint stress (CRS) in Charles-Foster rats, Antiulcer activity of plant extract was compared with famotidine (H2-antagonist) and sodium valproate (anti-epileptic). Plant extract, formotidine and sodium valproate showed a dose dependent reduction of gastric ulceration. Plant extract increased brain GABA level which was also dose dependent. Pretreatment with bicuculline methiodide (specific GABAA-antagonist) at the dose level of 0.5 mg/kg im, reversed the antiulcerogenic activity of both plant extract and sodium valproate. Bicuculline as such did not induce gastric ulceration in normal rat.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Plantas Medicinales
/
Ratas
/
Ratas Endogámicas
/
Úlcera Gástrica
/
Estrés Fisiológico
/
Encéfalo
/
Femenino
/
Masculino
/
Extractos Vegetales
/
Relación Dosis-Respuesta a Droga
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
1992
Tipo del documento:
Artículo
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