Antiulcer activity of N-phthaloyl GABA--a new GABA mimetic agent.
Indian J Exp Biol
;
1990 Feb; 28(2): 190-2
Artículo
en Inglés
| IMSEAR
| ID: sea-60068
ABSTRACT
N-phthaloyl GABA (P. GABA) inhibited gastric ulceration induced by 3 hr restraint stress at 4 degrees C (CRS) in albino rats. Antiulcer activity of P. GABA was compared with sodium valproate and cimetidine. P. GABA, sodium valproate and cimetidine showed a dose dependent reduction of gastric ulceration. Pretreatment with GABA antagonists-bicuculline methiodide (0.5 mg/kg, im) or 3 mercaptopropionic acid (2 mg/kg, im) reversed the antiulcerogenic activity of both the drugs (P. GABA and sodium valproate). GABA antagonists as such did not induce gastric ulceration in normal rats.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Ratas
/
Úlcera Gástrica
/
Bicuculina
/
Masculino
/
Ácido Valproico
/
Cimetidina
/
Relación Dosis-Respuesta a Droga
/
Ácido gamma-Aminobutírico
/
Animales
/
Ácido 3-Mercaptopropiónico
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
1990
Tipo del documento:
Artículo
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