Effect of simvastatin on fracture healing--an experimental study.
Indian J Exp Biol
;
2007 May; 45(5): 444-9
Artículo
en Inglés
| IMSEAR
| ID: sea-60106
ABSTRACT
Left femur was osteotomized and fixed with K wire in 21 rabbits. One group was fed simvastatin (120 mg/kg body wt/day) orally, whereas another group without medication served as control. Both groups were assessed radiologically, morphologically, histologically and biomechanically at 4, 8 and 12 weeks. An analysis of various parameters of study showed that simvastatin treated group had improved bone healing at 4 and 8 weeks of follow up, however, the difference was not significant statistically at 12 weeks. So it is concluded that Simvastatin favourably hastened the process of fracture healing in the rabbits at earlier phases.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Conejos
/
Estrés Mecánico
/
Factores de Tiempo
/
Resorción Ósea
/
Callo Óseo
/
Curación de Fractura
/
Simvastatina
/
Fracturas Óseas
/
Fémur
/
Animales
Tipo de estudio:
Estudios de evaluación
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
2007
Tipo del documento:
Artículo
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