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Prevention of chromate induced oxidative stress by alpha-lipoic acid.
Indian J Exp Biol ; 2005 Jun; 43(6): 531-5
Artículo en Inglés | IMSEAR | ID: sea-60259
ABSTRACT
The parenteral administration of alpha-lipoic acid (LA) protected against chromate induced oxidative stress in mouse liver. A shift in Cr induced pro-oxidant state to antioxidant-state by LA was noteworthy. The degree of protection was significant and similar in different LA administration regimens (prior-, co- and post- parenteral Cr exposure) explored. An improved status of the tissue antioxidants by LA appeared to be the mechanism of mitigation. The results are of chemopreventive value and suggest a possible alternative to ascorbic acid for abrogation of Cr toxicity.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Oxígeno / Dicromato de Potasio / Superóxido Dismutasa / Factores de Tiempo / Masculino / Carbono / Peroxidación de Lípido / Catalasa / Cromatos / Cromo Idioma: Inglés Revista: Indian J Exp Biol Año: 2005 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Oxígeno / Dicromato de Potasio / Superóxido Dismutasa / Factores de Tiempo / Masculino / Carbono / Peroxidación de Lípido / Catalasa / Cromatos / Cromo Idioma: Inglés Revista: Indian J Exp Biol Año: 2005 Tipo del documento: Artículo